Calcifying epithelial odontogenic tumor: report of three cases with immunohistochemical study

Calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic tumor. Here we report 3 cases of CEOT. All patients were women and the age of the patients ranged from 39-48 years. All cases were located in the maxilla. Histologically, one case was epithelial-predominant and consisted of large irregular cribriform sheets of polygonal epithelial cells, dense eosinophilic amyloid-like globules, and frequent concentric calcifications. The other two cases were amyloid-rich and consisted of scattered small nests of polygonal epithelial cells, abundant stroma with amyloid-like globules, and lacked calcifications. Immunohistochemically, tumor cells in all cases were diffusely strongly positive for AE1/AE3, cytokeratin (CK)5, Cam5.2, CK19, 34βE12, and p63. Tumor cells in two cases were positive for CK7 and in one case, they were positive for CD10. Vimentin was strongly positive in one case, whereas weakly positive in two cases. A variable number of CD1a-positive Langerhans cells were observed among nests of tumor cells in all cases. In summary, CEOT exhibits distinct but various histological and immunohistochemical features.